Wednesday, September 4, 2019
14.00 – 16.00 Registration
Opening Ceremony
16.00 Introduction and Welcome
Beate Averhoff (Frankfurt, Germany)
16.30 Opening Lecture
Acinetobacter baumannii: from the clinical management to the non-antimicrobial approaches
Jerónimo Pachón (Seville, Spain)
Session 1 Population genetics, evolution and comparative genomics
Chair Ellen Neidle (Athens, GA, USA)
Laurent Poirel (Fribourg, Switzerland)
17.00 Keynote Lecture 1
Tracking lineages of extensively antibiotic resistant GC1 and GC2 A. baumannii
Ruth Hall (Sydney, Australia)
17.30 – 18.30 Oral communications
17.30 O1-1
Allelic variation of pmrCAB operon is associated with Acinetobacter baumannii international clonal lineages and represents a genomic recombination site
Carolina S. Nodari (São Paulo, Brazil), R. Cayô, A.P. Streling, S. Gerson, J.Wille, H. Seifert, A.C. Gales, P.G. Higgins
17.45 O1-2
The evolutionary trajectory of Acinetobacter pathobiology
Bardya Djahanschiri (Frankfurt, Germany), R. Iruegas, M. Männl, S. Göttig, I. Ebersberger
18.00 O1-3
Structure and evolution of Acinetobacter baumannii plasmids
Miguel A. Cevallos (Cuernavaca, Mexico), A.D. Salgado-Camargo, S. Castro-Jaimes, R.M Gutierrez-Ríos, L.F. Lozano, L. Altamirano-Pacheco, J. Silva-Sanchez, Á. Pérez-Oseguera, P. Volkow, S. Castillo-Ramirez
18.15 O1-4
DNA single-strands cause microindel mutations
Klaus Harms (Tromsø, Norway), M.M. Liljegren, P.J. Johnsen
18.30 Welcome Reception
Thursday, September 5, 2019
Session 2 Insights into Acinetobacter baumannii virulence and pathogenicity
Chair Jerónimo Pachón (Seville, Spain)
Jordi Vila (Barcelona, Spain)
9.00 Keynote Lecture 2
Iron and Acinetobacter baumannii pathogenicity
Paolo Visca (Rome, Italy)
9.30 – 10.30 Oral communications
9.30 O2-1
Impact of the Acinetobacter trimeric autotransporter adhesin Ata on pathogenicity of Acinetobacter baumannii and the host cell response
Sonali Wohra (Frankfurt, Germany), L. Leukert, M. Weidensdorfer, I. Wittig, P. Kraiczy, V.A.J. Kempf, S. Göttig
9.45 O2-2
The Acinetobacter baumannii outer membrane protein CarO exhibits virulence factor roles in a murine infection model
Gema Labrador-Herrera (Seville, Spain), T. Cebrero-Cangueiro, Y. Smani, J. Pachón, A.M. Viale, J. Morán-Barrio, M.E. Pachón-Ibáñez
10.00 O2-3
CpaA, a novel secreted protease of Acinetobacter spp., targets host glycoproteins
M. Florencia Haurat (St. Louis, MO, USA), R.L. Kinsella, D. Urusova, N.H. Tolia, M.F. Feldman
10.15 O2-4
Potential mechanisms of mucin-enhanced Acinetobacter baumannii virulence in the mouse model of intraperitoneal infection
Wangxue Chen (Ottawa, Canada), G. Harris, B.E. Holbein, H.H. Xu, H. Zhou
10.30 – 11.00 Coffee Break
Session 3 Emergence and genetics of antibiotic resistance
Chair Harald Seifert (Cologne, Germany)
Spyros Pournaras (Athens, Greece)
11.00 Keynote Lecture 3
Role of rapid diagnostics in prevention and control of multidrug-resistant Acinetobacter
Laurent Poirel (Fribourg, Switzerland)
11.30 – 12.30 Oral communications
11.30 O3-1
Emergence of colistin resistance among carbapenemase-producing Acinetobacter baumannii clinical isolates from Egypt
Nevine S. Fam (Giza, Egypt), S.H. Mohamed, D. Gamal, R.M. Wasfy, M. Sherif, P.G. Higgins, A.A. El-Kholy
11.45 O3-2
Characterization of induced antibiotic tolerance in Acinetobacter baumannii
Michaelle Chojnacki (Rochester, NY, USA), C. Blanchard, A. Jacobs, D. Flaherty, P. Dunman
12.00 O3-3
Comparative characteristics of OXA-23/IC2, OXA-23/IC1, OXA-58/IC1 and OXA-58/IC2 carbapenem-resistant Acinetobacter baumannii
S. Vourli, P.G. Higgins, F. Runci, M. Machado, K. Dafopoulou, I. Artuso, J. Rossen, J.A. Carrico, J. Moran-Gilad, A. Tsakris, A.W. Friedrich, R. Zarrilli, H. Seifert, P. Visca, Spyros Pournaras (Athens, Greece)
12.15 O3-4
Evolution towards increased carbapenemase activity in OXA-51-like beta-lactamases of Acinetobacter baumannii
Y. Takebayashi, J. Findlay, K.J. Heesom, M.B. Avison, P.J. Warburton, Benjamin A. Evans (Cambridge, UK)
12.30 – 13.30 Lunch
13.30 – 14.30 Poster Session 1
Topics: 2, 3, 4, 5
Session 4 Genetics and regulation of infection
Chair Paolo Visca (Rome, Italy)
Beate Averhoff (Frankfurt, Germany)
14.30 Keynote Lecture 4
Regulation of a virulence switch in Acinetobacter baumannii
Phil Rather (Atlanta, GA, USA)
15.00 – 16.00 Oral communications
15.00 O4-1
Characterisation of antimicrobial resistance and virulence phenotypes in two-component regulatory system mutants from AB5075
Marta Marí-Almirall (Barcelona, Spain), C. Cosgaya, I. Roca, J. Vila
15.15 O4-2
Acinetobacter baumannii phenotypic variation in response to DNA damage is mediated by a 5’UTR recognized in Bacillus subtilis
C. Ching, Q. Shen, Y. Chai, Veronica G. Godoy-Carter (Boston, MA, USA)
15.30 O4-3
Interplay between the RND pump AdeIJK and transcriptional regulator AdeN impacts the antibiotic resistance and virulence of Acinetobacter baumannii
R. Patidar, Ayush Kumar (Winnipeg / MB, Canada)
15.45 O4-4
Identification of the diversity of Acinetobacter baumannii type VI secretion system effectors and characterisation of a novel effector/immunity pair
J.M. Lewis, D. Deveson Lucas, M. Harper, John D Boyce (Melbourne, Australia)
16.00 – 16.30 Coffee Break
Session 5 Metabolism and regulation
Chair Kevin Towner (Nottingham, UK)
Volker Müller (Frankfurt, Germany)
16.30 Keynote Lecture 5
Laboratory evolution made EASy: expanding metabolism in Acinetobacter baylyi ADP1
Ellen Neidle (Athens, GA, USA)
17.00 – 18.00 Oral communications
17.00 O5-1
Metabolic engineering of Acinetobacter baylyi ADP1 for upgrading non-conventional substrates
Suvi Santala (Tampere, Finland), J. Luo, V. Santala
17.15 O5-2
A regulator discovered to enhance lignin valorization by Acinetobacter baylyi ADP1 affects switching between virulent and avirulent states of Acinetobacter baumannii AB5075
Emily A. McIntyre (Athens, GA, USA), P.N. Rather, E.L. Neidle
17.30 O5-3
Molecular regulation of Acinetobacter baumannii biofilm formation
Brooke R. Tomlinson (Tampa, FL, USA), G.A. Denham, L.N. Shaw
17.45 O5-4
Adaptation of Acinetobacter baumannii to the human host and to osmotic stress
Jennifer Breisch (Frankfurt, Germany), B. Averhoff
18.30 Buses depart from the Biologicum for conference dinner
19.00 Conference Dinner
Friday, September 6, 2019
Session 6 Adaptation and persistence
Chair Phil Rather (Atlanta, GA, USA)
Klaas Martinus Pos (Frankfurt, Germany)
9.00 Keynote Lecture 6
Dry and salty: how Acinetobacter copes with low water stress
Volker Müller (Frankfurt, Germany)
9.30 – 10.30 Oral communications
9.30 O6-1
Structure of the osmotic stress protein MtlD from A. baumannii
Heng-Keat Tam (Frankfurt, Germany), N.D Ngu, S. Himpich, A. Herrmann, V. Müller, K.M. Pos
9.45 O6-2
Molecular basis for desiccation tolerance in Acinetobacter baumannii
Y. Oda, H.K. Huse, M.M. Shapiro, N.M. Lewis, X. Zhong, J.E. Bruce, C. Manoil, Caroline S. Harwood (Seattle, WA, USA)
10.00 O6-3
Molecular insights into the mechanisms that define the lipidomic landscape of Acinetobacter baumannii under membrane stress
J.-H. Jiang, F.G. Adams, M. Zang, M. Khorvash, S.L. Begg, T.W.T. Rupasinghe, V. Naidu, V.G. Pederick, J.J. Whittall, J.C. Paton, I.T. Paulsen, K.A. Hassan, C.A. McDevitt, A.Y. Peleg, Bart A. Eijkelkamp (Adelaide, Australia)
10.15 O6-4
Natural transformation promotes horizontal transfer of large antibiotic resistance islands in Acinetobacter baumannii
M.-H. Laaberki, A.-S. Godeux, A. Lupo, M. Haenni, Xavier Charpentier (Villeurbanne / France)
10.30 – 11.00 Coffee Break
Session 7 Global and local epidemiology of Acientobacter
Chair Ruth Hall (Sydney, Australia)
Stephan Göttig (Frankfurt, Germany)
11.00 Keynote Lecture 7
Molecular epidemiology of clinical, animal, and environmental isolates of A. baumannii
Paul Higgins (Cologne, Germany)
11.30 – 12.30 Oral communications
11.30 O7-1
Acinetobacter baumannii – jet stream rider
Gottfried Wilharm (Wernigerode, Germany), E. Skiebe, A. Łopińska, K. Weber, K. Görlitz, G. Meimers, M. Kasprzak, M. Bochenski, M. Tobółka, J. Siekiera, C. Schaudinn, T. Semmler, L. Jerzak
11.45 O7-2
Resistome and genomic epidemiology of Acinetobacter spp. and A. baumannii isolated from the natural non-hospital environment
Soon Keong Wee (Singapore), S.P. Sivalingam, S.B. Mustaffa, C.P. Loh, E.P.H. Yap
12.00 O7-3
Poly-clonal dissemination of Acinetobacter baumannii in Egyptian hospitals
Leena Al-Hassan (Brighton, UK)
12.15 O7-4
Antibiotic resistance features and molecular epidemiology of Acinetobacter baumannii clinical isolates from Pakistan
Nabil Karah (Umea, Sweden), I. Ahmad, F. Khalid, S.N. Wai, B. Eric, B.E. Uhlin
12.30 – 13.30 Lunch
13.30 – 14.30 Poster Session 2
Topics: 1, 6, 7, 8
Session 8 New therapeutic approaches
Chair Paul Higgins (Cologne, Germany)
Volkhard Kempf (Frankfurt, Germany)
14.30 Keynote Lecture 8
Future alternatives to treat infections caused by Acinetobacter baumannii
Jordi Vila (Barcelona, Spain)
15.00 – 16.00 Oral communications
15.00 O8-1
Elucidating mechanisms of colistin resistance and the efficacy of combination therapy in MDR/XDR/PDR Acinetobacter baumannii
A.A. Fayad, D. Abdulghani, W. Bazzi, G.F. Araj, Ghassan M. Matar (Beirut, Lebanon)
15.15 O8-2
A genetic strategy to identify promising Acinetobacter antibiotic targets
L. Gallagher, J. Bailey, Colin Manoil (Seattle, WA, USA)
15.30 O8-3
Genetics of Acinetobacter baumannii surface polysaccharides reveals insights into cell surface diversity useful for epidemiology and therapeutics research
S.M. Cahill, K.L. Wyres, K.E. Holt, R.M. Hall, Johanna J. Kenyon (Brisbane, Australia)
15.45 O8-4
Artilysin® – the ingenious way to control bacteria
Martin Grießl (Regensburg, Germany)
16.00 End of Symposium and Farewell
Beate Averhoff (Frankfurt, Germany)