| Wednesday, September 4, 2019 | |
| 14.00 – 16.00 | Registration |
| Opening Ceremony | |
| 16.00 | Introduction and Welcome |
| Beate Averhoff (Frankfurt, Germany) | |
| 16.30 | Opening Lecture |
| Acinetobacter baumannii: from the clinical management to the non-antimicrobial approaches | |
| Jerónimo Pachón (Seville, Spain) | |
| Session 1 | Population genetics, evolution and comparative genomics |
| Chair | Ellen Neidle (Athens, GA, USA) |
| Laurent Poirel (Fribourg, Switzerland) | |
| 17.00 | Keynote Lecture 1 |
| Tracking lineages of extensively antibiotic resistant GC1 and GC2 A. baumannii | |
| Ruth Hall (Sydney, Australia) | |
| 17.30 – 18.30 | Oral communications |
| 17.30 | O1-1 |
| Allelic variation of pmrCAB operon is associated with Acinetobacter baumannii international clonal lineages and represents a genomic recombination site | |
| Carolina S. Nodari (São Paulo, Brazil), R. Cayô, A.P. Streling, S. Gerson, J.Wille, H. Seifert, A.C. Gales, P.G. Higgins | |
| 17.45 | O1-2 |
| The evolutionary trajectory of Acinetobacter pathobiology | |
| Bardya Djahanschiri (Frankfurt, Germany), R. Iruegas, M. Männl, S. Göttig, I. Ebersberger | |
| 18.00 | O1-3 |
| Structure and evolution of Acinetobacter baumannii plasmids | |
| Miguel A. Cevallos (Cuernavaca, Mexico), A.D. Salgado-Camargo, S. Castro-Jaimes, R.M Gutierrez-Ríos, L.F. Lozano, L. Altamirano-Pacheco, J. Silva-Sanchez, Á. Pérez-Oseguera, P. Volkow, S. Castillo-Ramirez | |
| 18.15 | O1-4 |
| DNA single-strands cause microindel mutations | |
| Klaus Harms (Tromsø, Norway), M.M. Liljegren, P.J. Johnsen | |
| 18.30 | Welcome Reception |
| Thursday, September 5, 2019 | |
| Session 2 | Insights into Acinetobacter baumannii virulence and pathogenicity |
| Chair | Jerónimo Pachón (Seville, Spain) |
| Jordi Vila (Barcelona, Spain) | |
| 9.00 | Keynote Lecture 2 |
| Iron and Acinetobacter baumannii pathogenicity | |
| Paolo Visca (Rome, Italy) | |
| 9.30 – 10.30 | Oral communications |
| 9.30 | O2-1 |
| Impact of the Acinetobacter trimeric autotransporter adhesin Ata on pathogenicity of Acinetobacter baumannii and the host cell response | |
| Sonali Wohra (Frankfurt, Germany), L. Leukert, M. Weidensdorfer, I. Wittig, P. Kraiczy, V.A.J. Kempf, S. Göttig | |
| 9.45 | O2-2 |
| The Acinetobacter baumannii outer membrane protein CarO exhibits virulence factor roles in a murine infection model | |
| Gema Labrador-Herrera (Seville, Spain), T. Cebrero-Cangueiro, Y. Smani, J. Pachón, A.M. Viale, J. Morán-Barrio, M.E. Pachón-Ibáñez | |
| 10.00 | O2-3 |
| CpaA, a novel secreted protease of Acinetobacter spp., targets host glycoproteins | |
| M. Florencia Haurat (St. Louis, MO, USA), R.L. Kinsella, D. Urusova, N.H. Tolia, M.F. Feldman | |
| 10.15 | O2-4 |
| Potential mechanisms of mucin-enhanced Acinetobacter baumannii virulence in the mouse model of intraperitoneal infection | |
| Wangxue Chen (Ottawa, Canada), G. Harris, B.E. Holbein, H.H. Xu, H. Zhou | |
| 10.30 – 11.00 | Coffee Break |
| Session 3 | Emergence and genetics of antibiotic resistance |
| Chair | Harald Seifert (Cologne, Germany) |
| Spyros Pournaras (Athens, Greece) | |
| 11.00 | Keynote Lecture 3 |
| Role of rapid diagnostics in prevention and control of multidrug-resistant Acinetobacter | |
| Laurent Poirel (Fribourg, Switzerland) | |
| 11.30 – 12.30 | Oral communications |
| 11.30 | O3-1 |
| Emergence of colistin resistance among carbapenemase-producing Acinetobacter baumannii clinical isolates from Egypt | |
| Nevine S. Fam (Giza, Egypt), S.H. Mohamed, D. Gamal, R.M. Wasfy, M. Sherif, P.G. Higgins, A.A. El-Kholy | |
| 11.45 | O3-2 |
| Characterization of induced antibiotic tolerance in Acinetobacter baumannii | |
| Michaelle Chojnacki (Rochester, NY, USA), C. Blanchard, A. Jacobs, D. Flaherty, P. Dunman | |
| 12.00 | O3-3 |
| Comparative characteristics of OXA-23/IC2, OXA-23/IC1, OXA-58/IC1 and OXA-58/IC2 carbapenem-resistant Acinetobacter baumannii | |
| S. Vourli, P.G. Higgins, F. Runci, M. Machado, K. Dafopoulou, I. Artuso, J. Rossen, J.A. Carrico, J. Moran-Gilad, A. Tsakris, A.W. Friedrich, R. Zarrilli, H. Seifert, P. Visca, Spyros Pournaras (Athens, Greece) | |
| 12.15 | O3-4 |
| Evolution towards increased carbapenemase activity in OXA-51-like beta-lactamases of Acinetobacter baumannii | |
| Y. Takebayashi, J. Findlay, K.J. Heesom, M.B. Avison, P.J. Warburton, Benjamin A. Evans (Cambridge, UK) | |
| 12.30 – 13.30 | Lunch |
| 13.30 – 14.30 | Poster Session 1 |
| Topics: 2, 3, 4, 5 | |
| Session 4 | Genetics and regulation of infection |
| Chair | Paolo Visca (Rome, Italy) |
| Beate Averhoff (Frankfurt, Germany) | |
| 14.30 | Keynote Lecture 4 |
| Regulation of a virulence switch in Acinetobacter baumannii | |
| Phil Rather (Atlanta, GA, USA) | |
| 15.00 – 16.00 | Oral communications |
| 15.00 | O4-1 |
| Characterisation of antimicrobial resistance and virulence phenotypes in two-component regulatory system mutants from AB5075 | |
| Marta Marí-Almirall (Barcelona, Spain), C. Cosgaya, I. Roca, J. Vila | |
| 15.15 | O4-2 |
| Acinetobacter baumannii phenotypic variation in response to DNA damage is mediated by a 5’UTR recognized in Bacillus subtilis | |
| C. Ching, Q. Shen, Y. Chai, Veronica G. Godoy-Carter (Boston, MA, USA) | |
| 15.30 | O4-3 |
| Interplay between the RND pump AdeIJK and transcriptional regulator AdeN impacts the antibiotic resistance and virulence of Acinetobacter baumannii | |
| R. Patidar, Ayush Kumar (Winnipeg / MB, Canada) | |
| 15.45 | O4-4 |
| Identification of the diversity of Acinetobacter baumannii type VI secretion system effectors and characterisation of a novel effector/immunity pair | |
| J.M. Lewis, D. Deveson Lucas, M. Harper, John D Boyce (Melbourne, Australia) | |
| 16.00 – 16.30 | Coffee Break |
| Session 5 | Metabolism and regulation |
| Chair | Kevin Towner (Nottingham, UK) |
| Volker Müller (Frankfurt, Germany) | |
| 16.30 | Keynote Lecture 5 |
| Laboratory evolution made EASy: expanding metabolism in Acinetobacter baylyi ADP1 | |
| Ellen Neidle (Athens, GA, USA) | |
| 17.00 – 18.00 | Oral communications |
| 17.00 | O5-1 |
| Metabolic engineering of Acinetobacter baylyi ADP1 for upgrading non-conventional substrates | |
| Suvi Santala (Tampere, Finland), J. Luo, V. Santala | |
| 17.15 | O5-2 |
| A regulator discovered to enhance lignin valorization by Acinetobacter baylyi ADP1 affects switching between virulent and avirulent states of Acinetobacter baumannii AB5075 | |
| Emily A. McIntyre (Athens, GA, USA), P.N. Rather, E.L. Neidle | |
| 17.30 | O5-3 |
| Molecular regulation of Acinetobacter baumannii biofilm formation | |
| Brooke R. Tomlinson (Tampa, FL, USA), G.A. Denham, L.N. Shaw | |
| 17.45 | O5-4 |
| Adaptation of Acinetobacter baumannii to the human host and to osmotic stress | |
| Jennifer Breisch (Frankfurt, Germany), B. Averhoff | |
| 18.30 | Buses depart from the Biologicum for conference dinner |
| 19.00 | Conference Dinner |
| Friday, September 6, 2019 | |
| Session 6 | Adaptation and persistence |
| Chair | Phil Rather (Atlanta, GA, USA) |
| Klaas Martinus Pos (Frankfurt, Germany) | |
| 9.00 | Keynote Lecture 6 |
| Dry and salty: how Acinetobacter copes with low water stress | |
| Volker Müller (Frankfurt, Germany) | |
| 9.30 – 10.30 | Oral communications |
| 9.30 | O6-1 |
| Structure of the osmotic stress protein MtlD from A. baumannii | |
| Heng-Keat Tam (Frankfurt, Germany), N.D Ngu, S. Himpich, A. Herrmann, V. Müller, K.M. Pos | |
| 9.45 | O6-2 |
| Molecular basis for desiccation tolerance in Acinetobacter baumannii | |
| Y. Oda, H.K. Huse, M.M. Shapiro, N.M. Lewis, X. Zhong, J.E. Bruce, C. Manoil, Caroline S. Harwood (Seattle, WA, USA) | |
| 10.00 | O6-3 |
| Molecular insights into the mechanisms that define the lipidomic landscape of Acinetobacter baumannii under membrane stress | |
| J.-H. Jiang, F.G. Adams, M. Zang, M. Khorvash, S.L. Begg, T.W.T. Rupasinghe, V. Naidu, V.G. Pederick, J.J. Whittall, J.C. Paton, I.T. Paulsen, K.A. Hassan, C.A. McDevitt, A.Y. Peleg, Bart A. Eijkelkamp (Adelaide, Australia) | |
| 10.15 | O6-4 |
| Natural transformation promotes horizontal transfer of large antibiotic resistance islands in Acinetobacter baumannii | |
| M.-H. Laaberki, A.-S. Godeux, A. Lupo, M. Haenni, Xavier Charpentier (Villeurbanne / France) | |
| 10.30 – 11.00 | Coffee Break |
| Session 7 | Global and local epidemiology of Acientobacter |
| Chair | Ruth Hall (Sydney, Australia) |
| Stephan Göttig (Frankfurt, Germany) | |
| 11.00 | Keynote Lecture 7 |
| Molecular epidemiology of clinical, animal, and environmental isolates of A. baumannii | |
| Paul Higgins (Cologne, Germany) | |
| 11.30 – 12.30 | Oral communications |
| 11.30 | O7-1 |
| Acinetobacter baumannii – jet stream rider | |
| Gottfried Wilharm (Wernigerode, Germany), E. Skiebe, A. Łopińska, K. Weber, K. Görlitz, G. Meimers, M. Kasprzak, M. Bochenski, M. Tobółka, J. Siekiera, C. Schaudinn, T. Semmler, L. Jerzak | |
| 11.45 | O7-2 |
| Resistome and genomic epidemiology of Acinetobacter spp. and A. baumannii isolated from the natural non-hospital environment | |
| Soon Keong Wee (Singapore), S.P. Sivalingam, S.B. Mustaffa, C.P. Loh, E.P.H. Yap | |
| 12.00 | O7-3 |
| Poly-clonal dissemination of Acinetobacter baumannii in Egyptian hospitals | |
| Leena Al-Hassan (Brighton, UK) | |
| 12.15 | O7-4 |
| Antibiotic resistance features and molecular epidemiology of Acinetobacter baumannii clinical isolates from Pakistan | |
| Nabil Karah (Umea, Sweden), I. Ahmad, F. Khalid, S.N. Wai, B. Eric, B.E. Uhlin | |
| 12.30 – 13.30 | Lunch |
| 13.30 – 14.30 | Poster Session 2 |
| Topics: 1, 6, 7, 8 | |
| Session 8 | New therapeutic approaches |
| Chair | Paul Higgins (Cologne, Germany) |
| Volkhard Kempf (Frankfurt, Germany) | |
| 14.30 | Keynote Lecture 8 |
| Future alternatives to treat infections caused by Acinetobacter baumannii | |
| Jordi Vila (Barcelona, Spain) | |
| 15.00 – 16.00 | Oral communications |
| 15.00 | O8-1 |
| Elucidating mechanisms of colistin resistance and the efficacy of combination therapy in MDR/XDR/PDR Acinetobacter baumannii | |
| A.A. Fayad, D. Abdulghani, W. Bazzi, G.F. Araj, Ghassan M. Matar (Beirut, Lebanon) | |
| 15.15 | O8-2 |
| A genetic strategy to identify promising Acinetobacter antibiotic targets | |
| L. Gallagher, J. Bailey, Colin Manoil (Seattle, WA, USA) | |
| 15.30 | O8-3 |
| Genetics of Acinetobacter baumannii surface polysaccharides reveals insights into cell surface diversity useful for epidemiology and therapeutics research | |
| S.M. Cahill, K.L. Wyres, K.E. Holt, R.M. Hall, Johanna J. Kenyon (Brisbane, Australia) | |
| 15.45 | O8-4 |
| Artilysin® – the ingenious way to control bacteria | |
| Martin Grießl (Regensburg, Germany) | |
| 16.00 | End of Symposium and Farewell |
| Beate Averhoff (Frankfurt, Germany) |
